Associate Principal Scientist, Regenerative Immunology

ICR's Regenerative Immunology program is focused on regenerating the aging immune system, the decline of which underlies many of the most devastating age-related diseases. We're hiring a Principal Scientist to lead our Thymic Regeneration Team to restore thymic function and rejuvenate adaptive immunity. You'll need a deep background in immunology, thymic biology and iPSCs.With ICR, you'll get to:Lead a cutting-edge team developing iPSC-derived thymic epithelial cells (iTECs) and thymic organoids to rejuvenate the aging immune systemContribute highly practical and readily translatable thymic regeneration, immune reconstitution and rejuvenative medicine ideasDesign and optimize directed-differentiation protocols to generate functional, TECs from human iPSCsBuild, characterize and validate 3D thymic organoids capable of supporting de novo T-cell developmentCollaborate with other ICR scientists and groups to advance immune rejuvenation under a personalized medicine paradigmPlease apply if you have:A PhD or MD/PhDAt least 10 years of research experience, preferably in thymic biology, stem cell differentiation, organoid engineering or regenerative immunologyCurrent and in-depth knowledge of thymic epithelial cell biology, iPSC directed differentiation, T-cell development and tissue engineeringIdeally, you'll also have:Expert knowledge of thymic epithelial cell ontogeny, FOXN1 biology, T-cell selection and thymic niche reconstitutionExperience with iPSC culture, directed differentiation, 3D organoid culture, single-cell genomics, RNAseq, flow cytometry, immunofluorescent microscopy, CRISPR gene editing and cell cultureExperience with in vivo transplantation, humanized mouse models and assessment of functional immune reconstitutionEven if you don't meet all of these criteria, please apply anywayAnd you'll need:An easygoing, friendly personalityThe ability to work in the United States without sponsorshipIf you don't combine your cover letter with your CV or resume when you apply through LinkedIn, after you apply please send your cover letter only to: apply@invitroresearch.com with "Cover [Your name]" as the Subject line.Position title and compensation are commensurate with experience.The compensation ranges listed below are starting ranges.Starting base pay range: $160,000/yr - $215,000/yrStarting bonus range: $10,000/yr - $20,000/yr