Senior Scientist (NMR)

About Ten63 TherapeuticsTen63 Therapeutics is focused on improving human health by developing better, more durable therapeutics against cancer and some of the world's most lethal diseases. We are leveraging our proprietary in silico platform BEYOND to generate novel therapeutics to hit previously undruggable targets. We're pioneering an engineered approach to drug discovery by scaling quantum simulations and fusing them with generative chemistry to tackle previously undruggable, high-impact targets. Our team of pioneering scientists, engineers, drug hunters, and quantum chemists values passion, teamwork, out of the box thinking and determination to solve even what seems impossible. We embrace diversity and are committed towards inclusion.Position OverviewWe are seeking an exceptional Senior Scientist to help drug the undruggable through cutting-edge computational drug design. As a key member of the Biology team, this hands-on role requires deep experience with protein and small molecule NMR techniques to support structure-based drug discovery. You will design and purify challenging protein targets and demonstrate binding of BEYOND-designed small molecules using NMR and orthogonal biophysical methods. You will collaborate in a dynamic interdisciplinary environment with structural biologists, biophysicists, biochemists, cell biologists, medicinal chemists, molecular dynamics modelers, and engineers building cutting-edge computational algorithms. This is an in-person lab-based position and will require reimbursed local travel to NMR facilities.ResponsibilitiesDesign expression constructs and purify disease-relevant, challenging protein targetsOwn NMR strategy and execution at Ten63, including ligand- and protein-based methods to assess small molecule binding, elucidate binding sites and binding modes, and build understanding of protein dynamicsCollaborate meaningfully with other members of the Biology, Chemistry, Design, and Engineering teams to meet company and project goalsCommunicate results clearly to a diverse multidisciplinary teamRequired QualificationsPhD or equivalent experience in Biophysics, Structural Biology, or a related field4+ years of relevant biotech/biopharma industry experienceProven experience purifying challenging proteins using a broad array of purification techniquesDeep and demonstrated expertise in NMR (protein and small molecule)Ability to design rigorous experiments, troubleshoot independently, and communicate results across biology, chemistry, and computational teamsPassion for tackling difficult therapeutic targets and working in an interdisciplinary discovery environmentPreferred QualificationsExperience with orthogonal biophysical techniques for small molecule binding a plus (SPR, nanoDSF, ITC, etc.)Experience working in a drug discovery roleWhat We OfferOpportunity to work on previously undruggable targets and fundamentally change the paradigm of drug discoveryCollaborative environment with world-class scientists, engineers, drug hunters, and quantum chemistsCompetitive compensation package including equity and an annual bonusComprehensive health, life, short- and long-term disability insurance policies401K matchingFree gym membershipBeautiful, modern lab space in an award-winning building located in the heart of Research Triangle ParkProfessional development opportunitiesTen63 Therapeutics is an equal opportunity employer. We embrace diversity and are committed towards inclusion. We encourage applications from all qualified candidates regardless of race, color, religion, sex, national origin, age, disability, or any other protected characteristic.