Scientist - Aviner/Andino labs

Can we make live vaccines safer by controlling how a virus is translated in specific cell types?We’re hiring a full-time Scientist to lead an experimental program at the intersection of RNA biology, high-throughput functional genomics, and molecular virology.The project: A fully funded 2-year effort focused on rational viral genome engineering and cell type-specific translational control to develop live-attenuated vaccines.

Location: On-site at UCSF Mission Bay (San Francisco, CA)Start Date: ImmediateWhat you’ll own:

• Design, construction, and execution of massively parallel reporter assays (MPRAs) to measure cell type-specific translation dynamics
• End-to-end wet lab execution: library construction, in vitro RNA synthesis, delivery into human cell cultures, and NGS quantification
• Translating high-throughput screen outputs directly into targeted viral attenuation candidatesWho you are:
• Ph.D. in Molecular Biology, Biochemistry, Microbiology or related field
• Deep technical command of RNA workflows from data collection to analysis
• Independent problem solver: you’ve taken a messy experimental problem from idea to clean data without someone telling you how
• Preferred but not required: experience with high-throughput reporter or CRISPR screens, molecular virology, neuronal culturesTo apply:Email your CV and a brief summary of your relevant experience to ranen.aviner@ucsf.edu with the subject line "Scientist Application: Viral Attenuation".Optional: To help us evaluate your fit, feel free to include a short note describing a specific technical hurdle or unexpected failure at the bench and step-by-step logic you applied to resolve it.